Importin 9 antibody (AA 827-1041)

Catalog No. ABIN6142507

Product Details anti-Importin 9 Antibody

Target: Importin 9 (IPO9)

Binding Specificity: AA 827-1041

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 9 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LPGPTGKPAL EFVMAEWTSR QHLFYGQYEG KVSSVALCKL LQHGINADDK RLQDIRVKGE EIYSMDEGIR TRSKSAKNPE RWTNIPLLVK ILKLIINELS NVMEANAARQ ATPAEWSQDD SNDMWEDQEE EEEEEEDGLA GQLLSDILAT SKYEEDYYED DEEDDPDALK DPLYQIDLQA YLTDFLCQFA QQPCYIMFSG HLNDNERRVL QTIGI

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 827-1041 of human IPO9 (NP_060555.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Importin 9

Target: Importin 9 (IPO9)

Alternative Name: IPO9 (IPO9 Products)

Synonyms: Imp9 antibody, 0710008K06Rik antibody, AI845704 antibody, C78347 antibody, Ranbp9 antibody, mKIAA1192 antibody, zgc:66429 antibody, wu:fc23d12 antibody, MGC81741 antibody, IPO9 antibody, DDBDRAFT_0205722 antibody, DDBDRAFT_0229883 antibody, DDB_0205722 antibody, DDB_0229883 antibody, RGD1561940 antibody, RanBPM antibody, RanBP9 antibody, bpm-l antibody, bpm90 antibody, ranbp9 antibody, ranbp9-a antibody, ranbp9-b antibody, ranbp9b antibody, cb457 antibody, zgc:158650 antibody, importin 9 antibody, importin 9 L homeolog antibody, RAN binding protein 9 antibody, RAN binding protein 9 L homeolog antibody, IPO9 antibody, Ipo9 antibody, ipo9 antibody, ipo9.L antibody, cnrP antibody, Ranbp9 antibody, ranbp9.L antibody, RANBP9 antibody, ranbp9 antibody

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. Mediates the nuclear import of actin (By similarity.,IPO9,Imp9,IPO9

Molecular Weight: 115 kDa

Gene ID: 55705

UniProt: Q96P70

Pathways: Protein targeting to Nucleus