IFIT2 antibody (AA 273-472)

Catalog No. ABIN6142178

Product Details anti-IFIT2 Antibody

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Binding Specificity: AA 273-472

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFIT2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ALEYIPNNAY LHCQIGCCYR AKVFQVMNLR ENGMYGKRKL LELIGHAVAH LKKADEANDN LFRVCSILAS LHALADQYED AEYYFQKEFS KELTPVAKQL LHLRYGNFQL YQMKCEDKAI HHFIEGVKIN QKSREKEKMK DKLQKIAKMR LSKNGADSEA LHVLAFLQEL NEKMQQADED SERGLESGSL IPSASSWNGE

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IFIT2

Target: IFIT2 (Interferon-Induced Protein with Tetratricopeptide Repeats 2 (IFIT2))

Alternative Name: IFIT2 (IFIT2 Products)

Synonyms: G10P2 antibody, GARG-39 antibody, IFI-54 antibody, IFI-54K antibody, IFI54 antibody, IFIT-2 antibody, ISG-54 K antibody, ISG-54K antibody, ISG54 antibody, P54 antibody, cig42 antibody, wu:fb58d07 antibody, DKFZp468G198 antibody, AV302338 antibody, Ifi54 antibody, interferon induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 2 antibody, interferon-induced protein with tetratricopeptide repeats 15 antibody, IFIT2 antibody, Ifit2 antibody, ifit15 antibody

Background: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism. Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.,IFIT2,G10P2,GARG-39,IFI-54,IFI-54K,IFI54,IFIT-2,ISG-54 K,ISG-54K,ISG54,P54,cig42,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microtubules,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,IFIT2

Molecular Weight: 54 kDa

Gene ID: 3433

UniProt: P09913