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HSPA2 antibody (AA 400-639)

HSPA2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6142040
  • Target See all HSPA2 Antibodies
    HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))
    Binding Specificity
    • 8
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    AA 400-639
    Reactivity
    • 47
    • 25
    • 17
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 38
    • 17
    Rabbit
    Clonality
    • 31
    • 24
    Polyclonal
    Conjugate
    • 29
    • 9
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This HSPA2 antibody is un-conjugated
    Application
    • 40
    • 15
    • 12
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    TPLSLGIETA GGVMTPLIKR NTTIPTKQTQ TFTTYSDNQS SVLVQVYEGE RAMTKDNNLL GKFDLTGIPP APRGVPQIEV TFDIDANGIL NVTAADKSTG KENKITITND KGRLSKDDID RMVQEAERYK SEDEANRDRV AAKNALESYT YNIKQTVEDE KLRGKISEQD KNKILDKCQE VINWLDRNQM AEKDEYEHKQ KELERVCNPI ISKLYQGGPG GGSGGGGSGA SGGPTIEEVD
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 400-639 of human HSPA2 (NP_068814.2).
    Isotype
    IgG
    Top Product
    Discover our top product HSPA2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HSPA2 (Heat Shock 70kDa Protein 2 (HSPA2))
    Alternative Name
    HSPA2 (HSPA2 Products)
    Synonyms
    HSP70-2 antibody, HSP70-3 antibody, HSPA2 antibody, DKFZp468B217 antibody, 70kDa antibody, HSP70.2 antibody, HSP70A2 antibody, Hsp70-2 antibody, Hspt70 antibody, Hst70 antibody, HSPA3 antibody, heat shock protein family A (Hsp70) member 2 antibody, heat shock protein Hsp20 antibody, heat shock 70kDa protein 2 antibody, heat shock protein 2 antibody, heat shock protein family A member 2 antibody, HSPA2 antibody, hspA2 antibody, Hspa2 antibody
    Background
    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity.,HSPA2,HSP70-2,HSP70-3,Cancer,Tumor biomarkers,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,HSPA2
    Molecular Weight
    70 kDa
    Gene ID
    3306
    UniProt
    P54652
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