Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene.,HRH4,AXOR35,BG26,GPCR105,GPRv53,H4,H4R,HH4R,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Neuroscience,HRH4