EPAS1 antibody (AA 588-870)

Catalog No. ABIN6141764

Product Details anti-EPAS1 Antibody

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Binding Specificity: AA 588-870

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPAS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: FQQQLESKKT EPEHRPMSSI FFDAGSKASL PPCCGQASTP LSSMGGRSNT QWPPDPPLHF GPTKWAVGDQ RTEFLGAAPL GPPVSPPHVS TFKTRSAKGF GARGPDVLSP AMVALSNKLK LKRQLEYEEQ AFQDLSGGDP PGGSTSHLMW KRMKNLRGGS CPLMPDKPLS ANVPNDKFTQ NPMRGLGHPL RHLPLPQPPS AISPGENSKS RFPPQCYATQ YQDYSLSSAH KVSGMASRLL GPSFESYLLP ELTRYDCEVN VPVLGSSTLL QGGDLLRALD QAT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 588-870 of human EPAS1/HIF2alpha (NP_001421.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Alternative Name: EPAS1 (EPAS1 Products)

Synonyms: EPAS1 antibody, ECYT4 antibody, HIF2A antibody, HLF antibody, MOP2 antibody, PASD2 antibody, bHLHe73 antibody, HIF-2alpha antibody, HRF antibody, Hif2a antibody, bhlhe73 antibody, ecyt4 antibody, hif2 antibody, hif2a antibody, hif2alpha antibody, hlf antibody, mop2 antibody, pasd2 antibody, EPAS antibody, EPAS-1 antibody, endothelial PAS domain protein 1 antibody, endothelial PAS domain protein 1 L homeolog antibody, EPAS1 antibody, epas1 antibody, Epas1 antibody, epas1.L antibody

Background: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.,EPAS1,ECYT4,HIF2A,HLF,MOP2,PASD2,bHLHe73,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Invasion and Metastasis,Endocrine & Metabolism,Nucleotide metabolism,Molecular processes,Cardiovascular,Angiogenesis,Hypoxia,HIF,EPAS1

Molecular Weight: 96 kDa

Gene ID: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect