GZMB antibody (AA 148-247)

Catalog No. ABIN6141553

Product Details anti-GZMB Antibody

Target: GZMB (Granzyme B (GZMB))

Binding Specificity: AA 148-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GZMB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: GQTAPLGKHS HTLQEVKMTV QEDRKCESDL RHYYDSTIEL CVGDPEIKKT SFKGDSGGPL VCNKVAQGIV SYGRNNGMPP RACTKVSSFV HWIKKTMKRY

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 148-247 of human Granzyme B (NP_004122.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GZMB

Target: GZMB (Granzyme B (GZMB))

Alternative Name: GZMB (GZMB Products)

Synonyms: CCPI antibody, CGL-1 antibody, CGL1 antibody, CSP-B antibody, CSPB antibody, CTLA1 antibody, CTSGL1 antibody, HLP antibody, SECT antibody, granzyme B antibody, GZMB antibody

Background: Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.,C11,CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT,Granzyme B,GZMB,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,GZMB

Molecular Weight: 27 kDa

Gene ID: 3002

UniProt: P10144

Pathways: Apoptosis, Caspase Cascade in Apoptosis