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GNA12 antibody (AA 1-200)

GNA12 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6141192
  • Target See all GNA12 Antibodies
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Binding Specificity
    • 15
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reactivity
    • 44
    • 15
    • 15
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Human
    Host
    • 44
    • 1
    Rabbit
    Clonality
    • 45
    Polyclonal
    Conjugate
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GNA12 antibody is un-conjugated
    Application
    • 20
    • 17
    • 13
    • 13
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    MSGVVRTLSR CLLPAEAGGA RERRAGSGAR DAEREARRRS RDIDALLARE RRAVRRLVKI LLLGAGESGK STFLKQMRII HGREFDQKAL LEFRDTIFDN ILKGSRVLVD ARDKLGIPWQ YSENEKHGMF LMAFENKAGL PVEPATFQLY VPALSALWRD SGIREAFSRR SEFQLGESVK YFLDNLDRIG QLNYFPSKQD
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GNA12 (NP_031379.2).
    Isotype
    IgG
    Top Product
    Discover our top product GNA12 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Alternative Name
    GNA12 (GNA12 Products)
    Synonyms
    NNX3 antibody, RMP antibody, gep antibody, gna12 antibody, gna12l antibody, AI414047 antibody, AI504261 antibody, Galpha12 antibody, G protein subunit alpha 12 antibody, guanine nucleotide binding protein (G protein) alpha 12a antibody, guanine nucleotide binding protein, alpha 12 antibody, GNA12 antibody, Gna12 antibody, gna12a antibody
    Background
    Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG. GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation. Together with NAPA promotes CDH5 localization to plasma membrane. May play a role in the control of cell migration through the TOR signaling cascade.,GNA12,NNX3,RMP,gep,Epigenetics & Nuclear Signaling,Translation Control,Regulation of eIF4 and p70 S6 Kinase,Signal Transduction,G protein signaling,mTOR Signaling Pathway,MAPK-JNK Signaling Pathway,GNA12
    Molecular Weight
    34 kDa/37 kDa/44 kDa
    Gene ID
    2768
    UniProt
    Q03113
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