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FURIN antibody (AA 120-370)

FURIN Reactivity: Human WB, IHC, IP, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6140815
  • Target See all FURIN Antibodies
    FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
    Binding Specificity
    • 15
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 120-370
    Reactivity
    • 38
    • 36
    • 16
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 52
    • 3
    • 3
    Rabbit
    Clonality
    • 45
    • 13
    Polyclonal
    Conjugate
    • 25
    • 10
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FURIN antibody is un-conjugated
    Application
    • 27
    • 18
    • 16
    • 13
    • 13
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    Sequence
    QQWYLSGVTQ RDLNVKAAWA QGYTGHGIVV SILDDGIEKN HPDLAGNYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA GEVAAVANNG VCGVGVAYNA RIGGVRMLDG EVTDAVEARS LGLNPNHIHI YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE HDSCNCDGYT NSIYTLSISS ATQFGNVPWY SEACSSTLAT TYSSGNQNEK QIVTTDLRQK CTESHTGTSA S
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 120-370 of human Furin (NP_002560.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
    Alternative Name
    FURIN (FURIN Products)
    Synonyms
    FURIN antibody, furin antibody, si:dkey-281a24.5 antibody, FUR antibody, LOC100220259 antibody, PACE antibody, spc1 antibody, xfurin antibody, MGC82710 antibody, PCSK3 antibody, SPC1 antibody, 9130404I01Rik antibody, Fur antibody, Pcsk3 antibody, Pace antibody, furin, paired basic amino acid cleaving enzyme antibody, furin (paired basic amino acid cleaving enzyme) a antibody, furin (paired basic amino acid cleaving enzyme) b antibody, furin, paired basic amino acid cleaving enzyme L homeolog antibody, furin (paired basic amino acid cleaving enzyme) antibody, FURIN antibody, furina antibody, furinb antibody, furin antibody, furin.L antibody, Furin antibody
    Background
    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.,FURIN,FUR,PACE,PCSK3,SPC1,furin,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Ubiquitin,Notch Signaling Pathway,Endocrine & Metabolism,FURIN
    Molecular Weight
    86 kDa
    Gene ID
    5045
    UniProt
    P09958
    Pathways
    Notch Signaling, Neurotrophin Signaling Pathway
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