Filamin A antibody (AA 2348-2647)

Catalog No. ABIN6140677

Product Details anti-Filamin A Antibody

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Binding Specificity: AA 2348-2647

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Filamin A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Sequence: NQPASFAVSL NGAKGAIDAK VHSPSGALEE CYVTEIDQDK YAVRFIPREN GVYLIDVKFN GTHIPGSPFK IRVGEPGHGG DPGLVSAYGA GLEGGVTGNP AEFVVNTSNA GAGALSVTID GPSKVKMDCQ ECPEGYRVTY TPMAPGSYLI SIKYGGPYHI GGSPFKAKVT GPRLVSNHSL HETSSVFVDS LTKATCAPQH GAPGPGPADA SKVVAKGLGL SKAYVGQKSS FTVDCSKAGN NMLLVGVHGP RTPCEEILVK HVGSRLYSVS YLLKDKGEYT LVVKWGDEHI PGSPYRVVVP

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 2348-2647 of human Filamin A (NP_001104026.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: FLNA (FLNA Products)

Background: The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.,FLNA,ABP-280,ABPX,CSBS,CVD1,FLN,FLN-A,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2,XLVD,XMVD,filamin-A,Epigenetics & Nuclear Signaling,RNA Binding,Signal Transduction,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Actins,FLNA

Molecular Weight: 280 kDa

Gene ID: 2316

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location