FIP1L1 antibody (AA 1-300)

Catalog No. ABIN6140640

Product Details anti-FIP1L1 Antibody

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FIP1L1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MSAGEVERLV SELSGGTGGD EEEEWLYGDE NEVERPEEEN ASANPPSGIE DETAENGVPK PKVTETEDDS DSDSDDDEDD VHVTIGDIKT GAPQYGSYGT APVNLNIKTG GRVYGTTGTK VKGVDLDAPG SINGVPLLEV DLDSFEDKPW RKPGADLSDY FNYGFNEDTW KAYCEKQKRI RMGLEVIPVT STTNKITAED CTMEVTPGAE IQDGRFNLFK VQQGRTGNSE KETALPSTKA EFTSPPSLFK TGLPPSRNST SSQSQTSTAS RKANSSVGKW QDRYGRAESP DLRRLPGAID

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human FIP1L1 (NP_001128409.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FIP1L1

Target: FIP1L1 (FIP1 Like 1 (FIP1L1))

Alternative Name: FIP1L1 (FIP1L1 Products)

Synonyms: FIP1 antibody, Rhe antibody, hFip1 antibody, 1300019H17Rik antibody, Rje antibody, fip1l1 antibody, wu:fd36f11 antibody, zgc:103421 antibody, factor interacting with PAPOLA and CPSF1 antibody, factor interacting with PAPOLA and CPSF1 S homeolog antibody, FIP1 like 1 (S. cerevisiae) antibody, FIP1 like 1b (S. cerevisiae) antibody, fip1l1 antibody, FIP1L1 antibody, fip1l1.S antibody, Fip1l1 antibody, fip1l1b antibody

Background: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,FIP1L1,FIP1,Rhe,hFip1,Epigenetics & Nuclear Signaling,RNA Binding,FIP1L1

Molecular Weight: 40 kDa/58 kDa/65 kDa/66 kDa

Gene ID: 81608

UniProt: Q6UN15