FGD4 antibody (AA 99-198)

Catalog No. ABIN6140588

Product Details anti-FGD4 Antibody

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Binding Specificity: AA 99-198

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD4 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: QMECEEEKAA TLSSDTSIQA SEPLLDTHIV NGERDETATA PASPTTDSCD GNASDSSYRT PGIGPVLPLE ERGAETETKV QERENGESPL ELEQLDQHHE

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human FGD4 (NP_640334.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Alternative Name: FGD4 (FGD4 Products)

Synonyms: CMT4H antibody, FRABP antibody, ZFYVE6 antibody, 9030023J02Rik antibody, 9330209B17Rik antibody, Frabp antibody, FYVE, RhoGEF and PH domain containing 4 antibody, FGD4 antibody, Fgd4 antibody

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.,FGD4,CMT4H,FRABP,ZFYVE6,FYVE,FGD4

Molecular Weight: 20 kDa/32 kDa/86 kDa

Gene ID: 121512

UniProt: Q96M96

Pathways: Neurotrophin Signaling Pathway