FBXW7 antibody (AA 408-707)

Catalog No. ABIN6140535

Product Details anti-FBXW7 Antibody

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Binding Specificity: AA 408-707

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: AVTGKCLRTL VGHTGGVWSS QMRDNIIISG STDRTLKVWN AETGECIHTL YGHTSTVRCM HLHEKRVVSG SRDATLRVWD IETGQCLHVL MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL QGHTNRVYSL QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG NADSTVKIWD IKTGQCLQTL QGPNKHQSAV TCLQFNKNFV ITSSDDGTVK LWDLKTGEFI RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL LVLDFDVDMK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 408-707 of human FBXW7 (NP_361014.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7 (FBXW7 Products)

Synonyms: cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene.,FBXW7,AGO,CDC4,FBW6,FBW7,FBX30,FBXO30,FBXW6,SEL-10,SEL10,hAgo,hCdc4,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,FBXW7

Molecular Weight: 66 kDa/70 kDa/79 kDa

Gene ID: 55294

UniProt: Q969H0

Pathways: Notch Signaling, EGFR Signaling Pathway