FAM208A antibody (AA 700-1000)

Catalog No. ABIN6140453

Product Details anti-FAM208A Antibody

Target: FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))

Binding Specificity: AA 700-1000

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Sequence: DTEDMRSKTV LKRKLEDLPE NMRKLAKTSN LSENCHLYEE SPQPIGSLGH DADLRRQQQD TCNSGIADIH RLFNWLSETL ANARHSDASL TDTVNKALGL STDDAYEELR QKHEYELNST PDKKDYEQPT CAKVENAQFK GTQSLLLEVD ATSKYSVAIS TSEVGTDHKL HLKEDPNLIS VNNFEDCSLC PSVPIEHGFR RQQSKSNNVE ETEIHWKLIP ITGGNARSPE DQLGKHGEKQ TPGMKSPEEQ LVCVPPQEAF PNDPRVINRQ RSSDYQFPSS PFTDTLKGTT EDDVLTGQVE E

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FAM208A

Target: FAM208A (Family with Sequence Similarity 208, Member A (FAM208A))

Alternative Name: FAM208A

Synonyms: c3orf63-a antibody, c3orf63.1 antibody, fam208a antibody, rap140 antibody, se89-1 antibody, C3orf63 antibody, RAP140 antibody, family with sequence similarity 208 member A L homeolog antibody, family with sequence similarity 208 member A antibody, fam208a.L antibody, FAM208A antibody

Background: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development (By similarity. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division (By similarity. Plays an important role in maintaining epiblast fitness or potency (By similarity.,FAM208A,C3orf63,RAP140,TASOR,se89-1,Epigenetics & Nuclear Signaling,RNA Binding,FAM208A

Molecular Weight: 139 kDa/170 kDa/182 kDa/189 kDa

Gene ID: 23272

UniProt: Q9UK61