ETV1 antibody (AA 80-300)

Catalog No. ABIN6140327

Product Details anti-ETV1 Antibody

Target: ETV1 (Ets Variant 1 (ETV1))

Binding Specificity: AA 80-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ETV1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: AFHGLPLKIK KEPHSPCSEI SSACSQEQPF KFSYGEKCLY NVSAYDQKPQ VGMRPSNPPT PSSTPVSPLH HASPNSTHTP KPDRAFPAHL PPSQSIPDSS YPMDHRFRRQ LSEPCNSFPP LPTMPREGRP MYQRQMSEPN IPFPPQGFKQ EYHDPVYEHN TMVGSAASQS FPPPLMIKQE PRDFAYDSEV PSCHSIYMRQ EGFLAHPSRT EGCMFEKGPR Q

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-300 of human ETV1 (NP_004947.2).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ETV1

Target: ETV1 (Ets Variant 1 (ETV1))

Alternative Name: ETV1 (ETV1 Products)

Synonyms: er81 antibody, XER81 antibody, MGC75591 antibody, ER81 antibody, Etsrp81 antibody, ETS variant 1 antibody, ets variant 1 antibody, ETS variant 1 S homeolog antibody, etv1 antibody, ETV1 antibody, Etv1 antibody, etv1.S antibody

Background: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.,ETV1,ER81,Epigenetics & Nuclear Signaling,Transcription Factors,Signal Transduction,MAPK-Erk Signaling Pathway,MAPK-P38 Signaling Pathway,Neuroscience,Stem Cells,Hematopoietic Progenitors,ETV1

Molecular Weight: 43 kDa/48 kDa/50 kDa/52 kDa/53 kDa/55 kDa

Gene ID: 2115

UniProt: P50549