EIF3C antibody (AA 694-913)

Catalog No. ABIN6140055

Product Details anti-EIF3C Antibody

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Binding Specificity: AA 694-913

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: EIPYMAAHES DARRRMISKQ FHHQLRVGER QPLLGPPESM REHVVAASKA MKMGDWKTCH SFIINEKMNG KVWDLFPEAD KVRTMLVRKI QEESLRTYLF TYSSVYDSIS METLSDMFEL DLPTVHSIIS KMIINEELMA SLDQPTQTVV MHRTEPTAQQ NLALQLAEKL GSLVENNERV FDHKQGTYGG YFRDQKDGYR KNEGYMRRGG YRQQQSQTAY

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 694-913 of human EIF3C (NP_003743.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EIF3C

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Alternative Name: EIF3C (EIF3C Products)

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3 complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC. The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.,EIF3C,EIF3CL,EIF3S8,eIF3-p110,Epigenetics & Nuclear Signaling,RNA Binding,Translation Control,EIF3C

Molecular Weight: 104 kDa/105 kDa

Gene ID: 8663

UniProt: Q99613

Pathways: Ribonucleoprotein Complex Subunit Organization