Endothelin 3 antibody (AA 17-187)

Catalog No. ABIN6139934

Product Details anti-Endothelin 3 Antibody

Target: Endothelin 3 (EDN3)

Binding Specificity: AA 17-187

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Endothelin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AGFVPCSQSG DAGRRGVSQA PTAARSEGDC EETVAGPGEE TVAGPGEGTV APTALQGPSP GSPGQEQAAE GAPEHHRSRR CTCFTYKDKE CVYYCHLDII WINTPEQTVP YGLSNYRGSF RGKRSAGPLP GNLQLSHRPH LRCACVGRYD KACLHFCTQT LDVSSNSRTA E

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 17-187 of human EDN3 (NP_996917.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Endothelin 3

Target: Endothelin 3 (EDN3)

Alternative Name: EDN3 (EDN3 Products)

Synonyms: et-3 antibody, EDN3 antibody, ET-3 antibody, ET3 antibody, HSCR4 antibody, PPET3 antibody, WS4B antibody, 114CH19 antibody, ls antibody, tmgc48 antibody, Et3 antibody, RGD1564825 antibody, preproET-3 antibody, endothelin-3 L homeolog antibody, endothelin 3 antibody, edn3.L antibody, EDN3 antibody, Edn3 antibody

Background: The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.,EDN3,ET-3,ET3,HSCR4,PPET3,WS4B,Cancer,Invasion and Metastasis,Signal Transduction,Neuroscience,EDN3

Molecular Weight: 23 kDa/25 kDa

Gene ID: 1908

UniProt: P14138

Pathways: Hormone Transport, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones