DYNC2H1 antibody (AA 1-250)

Catalog No. ABIN6139887

Product Details anti-DYNC2H1 Antibody

Target: DYNC2H1 (Dynein, Cytoplasmic 2, Heavy Chain 1 (DYNC2H1))

Binding Specificity: AA 1-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DYNC2H1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MANGTADVRK LFIFTTTQNY FGLMSELWDQ PLLCNCLEIN NFLDDGNQML LRVQRSDAGI SFSNTIEFGD TKDKVLVFFK LRPEVITDEN LHDNILVSSM LESPISSLYQ AVRQVFAPML LKDQEWSRNF DPKLQNLLSE LEAGLGIVLR RSDTNLTKLK FKEDDTRGIL TPSDEFQFWI EQAHRGNKQI SKERANYFKE LFETIAREFY NLDSLSLLEV VDLVETTQDV VDDVWRQTEH DHYPESRMLH

Cross-Reactivity: Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human DYNC2H1 (NP_001073932.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for DYNC2H1

Target: DYNC2H1 (Dynein, Cytoplasmic 2, Heavy Chain 1 (DYNC2H1))

Alternative Name: DYNC2H1 (DYNC2H1 Products)

Background: This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins.,DYNC2H1,ATD3,DHC1b,DHC2,DNCH2,DYH1B,SRPS2B,SRTD3,hdhc11,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centromere,Cytoskeleton,Motor Proteins,DYNC2H1

Molecular Weight: 105 kDa/492 kDa/493 kDa

Gene ID: 79659

UniProt: Q8NCM8

Pathways: Hedgehog Signaling, Asymmetric Protein Localization