Cullin 5 antibody (AA 1-300)

Catalog No. ABIN6139259

Product Details anti-Cullin 5 Antibody

Target: Cullin 5 (CUL5)

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 5 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CUL5 (NP_003469.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Cullin 5

Target: Cullin 5 (CUL5)

Alternative Name: CUL5 (CUL5 Products)

Synonyms: cul5 antibody, wu:fd17d09 antibody, wu:fi20h12 antibody, xx:11fd17d09 antibody, zgc:66185 antibody, Xcullin5 antibody, CG1401 antibody, CUL5 antibody, Cul5 antibody, Cullin 5 antibody, Cullin5 antibody, Dmel\\CG1401 antibody, cul-5 antibody, vacm-1 antibody, vacm1 antibody, VACM-1 antibody, VACM1 antibody, 4921514I20Rik antibody, 8430423K24Rik antibody, AI852817 antibody, C030032G03Rik antibody, C330021I08Rik antibody, Cullin-5 antibody, cullin 5a antibody, cullin 5 L homeolog antibody, Cullin 5 antibody, cullin 5 antibody, Cullin-5 antibody, cul5a antibody, cul5.L antibody, Cul5 antibody, CUL5 antibody, cul5 antibody, cul-5 antibody

Background: Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1 seems to direct ubiquitination of JAK2. ECS(KLHDC1 complex is part of the DesCEND (destruction via C-end degrons pathway and mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. May form a cell surface vasopressin receptor.,CUL5,CUL-5,VACM-1,VACM1,cullin-5,Cell Biology & Developmental Biology,Apoptosis,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,CUL5

Molecular Weight: 90 kDa

Gene ID: 8065

UniProt: Q93034

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development