CTSC antibody (AA 25-134)

Catalog No. ABIN6139221

Product Details anti-CTSC Antibody

Target: CTSC (Cathepsin C (CTSC))

Binding Specificity: AA 25-134

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTSC antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: DTPANCTYLD LLGTWVFQVG SSGSQRDVNC SVMGPQEKKV VVYLQKLDTA YDDLGNSGHF TIIYNQGFEI VLNDYKWFAF FKYKEEGSKV TTYCNETMTG WVHDVLGRNW

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 25-134 of human CTSC (NP_001805.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CTSC

Target: CTSC (Cathepsin C (CTSC))

Alternative Name: CTSC (CTSC Products)

Background: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis.,CTSC,CPPI,DPP-I,DPP1,DPPI,HMS,JP,JPD,PALS,PDON1,PLS,Cell Biology & Developmental Biology,Ubiquitin,CTSC

Molecular Weight: 15 kDa/51 kDa

Gene ID: 1075

UniProt: P53634