Exportin 2 antibody (AA 50-150)
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- Target See all Exportin 2 (CSE1L) Antibodies
- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
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Binding Specificity
- AA 50-150
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Exportin 2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LEKSQDNVIK VCASVTFKNY IKRNWRIVED EPNKICEADR VAIKANIVHL MLSSPEQIQK QLSDAISIIG REDFPQKWPD LLTEMVNRFQ SGDFHVINGV L
- Cross-Reactivity
- Human, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Exportin 2 (XPO2) (NP_001243064.1).
- Isotype
- IgG
- Top Product
- Discover our top product CSE1L Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:100 - 1:200
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
- Alternative Name
- CSE1L (CSE1L Products)
- Background
- Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.,CSE1L,CAS,CSE1,XPO2,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,CSE1L
- Molecular Weight
- 22 kDa/103 kDa/107 kDa/110 kDa
- Gene ID
- 1434
- UniProt
- P55060
- Pathways
- Protein targeting to Nucleus
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