COPS5 antibody (AA 1-334)

Catalog No. ABIN6138883

Product Details anti-COPS5 Antibody

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Binding Specificity: AA 1-334

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COPS5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MAASGSGMAQ KTWELANNMQ EAQSIDEIYK YDKKQQQEIL AAKPWTKDHH YFKYCKISAL ALLKMVMHAR SGGNLEVMGL MLGKVDGETM IIMDSFALPV EGTETRVNAQ AAAYEYMAAY IENAKQVGRL ENAIGWYHSH PGYGCWLSGI DVSTQMLNQQ FQEPFVAVVI DPTRTISAGK VNLGAFRTYP KGYKPPDEGP SEYQTIPLNK IEDFGVHCKQ YYALEVSYFK SSLDRKLLEL LWNKYWVNTL SSSSLLTNAD YTTGQVFDLS EKLEQSEAQL GRGSFMLGLE THDRKSEDKL AKATRDSCKT TIEAIHGLMS QVIKDKLFNQ INIS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human JAB1/CSN5/JAB1/CSN5/COPS5 (NP_006828.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COPS5

Target: COPS5 (COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis) (COPS5))

Alternative Name: COPS5 (COPS5 Products)

Synonyms: BcDNA.LD14392 antibody, BcDNA:LD14392 antibody, CG14884 antibody, CH5 antibody, CSN-5 antibody, Csn5 antibody, DCH5 antibody, Dch5 antibody, Dmel\\CG14884 antibody, JAB1 antibody, JAB1/CSN5 antibody, Jab1 antibody, JadBp antibody, csn5 antibody, dch5 antibody, jab1/csn5 antibody, l(3)89Cf antibody, l(3)L4032 antibody, l(3)M203 antibody, quo antibody, COPS5 antibody, MGC76063 antibody, AI303502 antibody, CSN5 antibody, Mov34 antibody, Sgn5 antibody, zgc:73130 antibody, MOV-34 antibody, SGN5 antibody, COP9 signalosome subunit 5 antibody, COP9 signalosome complex subunit 5 antibody, COP9 signalosome subunit 5 S homeolog antibody, CSN5 antibody, COPS5 antibody, cops5 antibody, CpipJ_CPIJ012314 antibody, Bm1_46585 antibody, VDBG_06932 antibody, LOAG_01443 antibody, csn5 antibody, Cops5 antibody, cops5.S antibody, csn-5 antibody

Background: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.,COPS5,CSN5,JAB1,MOV-34,SGN5,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,p53 pathway,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Ubiquitin,COPS5

Molecular Weight: 37 kDa

Gene ID: 10987

UniProt: Q92905

Pathways: Cell Division Cycle