COCH antibody (AA 20-260)

Catalog No. ABIN6138819

Product Details anti-COCH Antibody

Target: COCH (Cochlin (COCH))

Binding Specificity: AA 20-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COCH antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: GPAGSEGAAP IAITCFTRGL DIRKEKADVL CPGGCPLEEF SVYGNIVYAS VSSICGAAVH RGVISNSGGP VRVYSLPGRE NYSSVDANGI QSQMLSRWSA SFTVTKGKSS TQEATGQAVS TAHPPTGKRL KKTPEKKTGN KDCKADIAFL IDGSFNIGQR RFNLQKNFVG KVALMLGIGT EGPHVGLVQA SEHPKIEFYL KNFTSAKDVL FAIKEVGFRG GNSNTGKALK HTAQKFFTVD A

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human COCH (NP_001128530.1).

Isotype: IgG

Application Details

Application Notes: IHC,1:50 - 1:100,IF,1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COCH

Target: COCH (Cochlin (COCH))

Alternative Name: COCH (COCH Products)

Synonyms: AW122937 antibody, Coch-5B2 antibody, D12H14S564E antibody, COCH-5B2 antibody, COCH5B2 antibody, DFNA9 antibody, cochlin antibody, Coch antibody, COCH antibody

Background: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.,COCH,COCH-5B2,COCH5B2,DFNA9,cochlin,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Neuroscience,COCH

Molecular Weight: 53 kDa/59 kDa

Gene ID: 1690

UniProt: O43405

Pathways: Sensory Perception of Sound