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CNOT1 antibody (AA 2137-2376)

CNOT1 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6138777
  • Target See all CNOT1 Antibodies
    CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
    Binding Specificity
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    AA 2137-2376
    Reactivity
    • 16
    • 2
    • 1
    Human
    Host
    • 15
    • 1
    Rabbit
    Clonality
    • 16
    Polyclonal
    Conjugate
    • 9
    • 3
    • 2
    • 2
    This CNOT1 antibody is un-conjugated
    Application
    • 13
    • 6
    • 5
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    PRNMRLPDPF TPNLKVDMLS EINIAPRILT NFTGVMPPQF KKDLDSYLKT RSPVTFLSDL RSNLQVSNEP GNRYNLQLIN ALVLYVGTQA IAHIHNKGST PSMSTITHSA HMDIFQNLAV DLDTEGRYLF LNAIANQLRY PNSHTHYFSC TMLYLFAEAN TEAIQEQITR VLLERLIVNR PHPWGLLITF IELIKNPAFK FWNHEFVHCA PEIEKLFQSV AQCCMGQKQA QQVMEGTGAS
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 2137-2376 of human CNOT1 (NP_057368.3).
    Isotype
    IgG
    Top Product
    Discover our top product CNOT1 Primary Antibody
  • Application Notes
    WB,1:200 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))
    Alternative Name
    CNOT1 (CNOT1 Products)
    Synonyms
    CDC39 antibody, NOT1 antibody, NOT1H antibody, 6030411K04Rik antibody, AA815922 antibody, D830048B13 antibody, RGD1308009 antibody, GB18988 antibody, cdc39-like antibody, im:7141761 antibody, kiaa1007l antibody, wu:fc58h04 antibody, zgc:152902 antibody, CNOT1 antibody, not1 antibody, cdc39 antibody, not1h antibody, ad-005 antibody, NV18106 antibody, CCR4-NOT transcription complex subunit 1 antibody, CCR4-NOT transcription complex, subunit 1 antibody, CNOT1 antibody, Cnot1 antibody, LOC412371 antibody, cnot1 antibody, LOC100114396 antibody
    Background
    Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.,CNOT1,AD-005,CDC39,NOT1,NOT1H,Epigenetics & Nuclear Signaling,RNA Binding,CNOT1
    Molecular Weight
    173 kDa/241 kDa/266 kDa
    Gene ID
    23019
    UniProt
    A5YKK6
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance
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