Complement Factor I antibody (AA 19-300)

Catalog No. ABIN6138461

Product Details anti-Complement Factor I Antibody

Target: Complement Factor I (CFI)

Binding Specificity: AA 19-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor I antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KVTYTSQEDL VEKKCLAKKY THLSCDKVFC QPWQRCIEGT CVCKLPYQCP KNGTAVCATN RRSFPTYCQQ KSLECLHPGT KFLNNGTCTA EGKFSVSLKH GNTDSEGIVE VKLVDQDKTM FICKSSWSMR EANVACLDLG FQQGADTQRR FKLSDLSINS TECLHVHCRG LETSLAECTF TKRRTMGYQD FADVVCYTQK ADSPMDDFFQ CVNGKYISQM KACDGINDCG DQSDELCCKA CQGKGFHCKS GVCIPSQYQC NGEVDCITGE DEVGCAGFAS VA

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human CFI (NP_000195.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: CFI (CFI Products)

Synonyms: cfi antibody, MGC53615 antibody, Cfi antibody, factor I antibody, IF antibody, gb:ai721528 antibody, ahus3 antibody, c3b-ina antibody, c3bc4bi antibody, c3bina antibody, kaf antibody, CFI antibody, AHUS3 antibody, C3BINA antibody, C3b-INA antibody, FI antibody, KAF antibody, complement factor I S homeolog antibody, complement factor I L homeolog antibody, complement factor I antibody, complement component factor i antibody, cfi.S antibody, cfi.L antibody, CFI antibody, cfi antibody, Cfi antibody

Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.,CFI,AHUS3,ARMD13,C3BINA,C3b-INA,FI,IF,KAF,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,CFI

Molecular Weight: 65 kDa

Gene ID: 3426

UniProt: P05156

Pathways: Complement System