Cyclin E2 antibody (AA 255-404)

Catalog No. ABIN6138092

Product Details anti-Cyclin E2 Antibody

Target: Cyclin E2 (CCNE2)

Binding Specificity: AA 255-404

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin E2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: ALKDAPKVLL PQYSQETFIQ IAQLLDLCIL AIDSLEFQYR ILTAAALCHF TSIEVVKKAS GLEWDSISEC VDWMVPFVNV VKSTSPVKLK TFKKIPMEDR HNIQTHTNYL AMLEEVNYIN TFRKGGQLSP VCNGGIMTPP KSTEKPPGKH

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 255-404 of human Cyclin E2 (NP_477097.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Cyclin E2 antibody (ABIN6138092)

Wu, Fu, Liu, Li, Huang, Xue, Xu, Sun, Zhao, Mi: "Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs." in: Cell cycle (Georgetown, Tex.), Vol. 16, Issue 2, pp. 172-178, (2017) (PubMed).

Target Details for Cyclin E2

Target: Cyclin E2 (CCNE2)

Alternative Name: CCNE2 (CCNE2 Products)

Synonyms: ccne2 antibody, MGC53684 antibody, MGC132360 antibody, cb165 antibody, sb:cb165 antibody, zgc:86724 antibody, CCNE2 antibody, cyce2 antibody, CYCE2 antibody, cyclin E2 antibody, cyclin E2 L homeolog antibody, cyclin E1 L homeolog antibody, CCNE2 antibody, ccne2.L antibody, ccne2 antibody, ccne1.L antibody, Ccne2 antibody

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells.,CCNE2,CYCE2,cyclin E2,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cyclins,G1/S Checkpoint,Hedgehog Signaling Pathway,CCNE2

Molecular Weight: 41 kDa/46 kDa

Gene ID: 9134

UniProt: O96020

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases