CASC5 antibody (AA 1-300)
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- Target See all CASC5 Antibodies
- CASC5 (Cancer Susceptibility Candidate 5 (CASC5))
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Binding Specificity
- AA 1-300
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CASC5 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Sequence
- MDGVSSEANE ENDNIERPVR RRHSSILKPP RSPLQDLRGG NERVQESNAL RNKKNSRRVS FADTIKVFQT ESHMKIVRKS EMEGCSAMVP SQLQLLPPGF KRFSCLSLPE TETGENLLLI QNKKLEDNYC EITGMNTLLS APIHTQMQQK EFSIIEHTRE RKHANDQTVI FSDENQMDLT SSHTVMITKG LLDNPISEKS TKIDTTSFLA NLKLHTEDSR MKKEVNFSVD QNTSSENKID FNDFIKRLKT GKCSAFPDVP DKENFEIPIY SKEPNSASST HQMHVSLKED ENNSNITRLF
- Cross-Reactivity
- Human, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3).
- Isotype
- IgG
- Top Product
- Discover our top product CASC5 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CASC5 (Cancer Susceptibility Candidate 5 (CASC5))
- Alternative Name
- CASC5 (CASC5 Products)
- Synonyms
- AF15Q14 antibody, CT29 antibody, D40 antibody, KNL1 antibody, PPP1R55 antibody, Spc7 antibody, hKNL-1 antibody, hSpc105 antibody, 2310043D08Rik antibody, 5730505K17Rik antibody, Rad51 antibody, kinetochore scaffold 1 antibody, Kinetochore null protein 1 antibody, KNL1 antibody, Knl1 antibody, knl-1 antibody
- Background
- The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.,AF15Q14,CASC5,CT29,D40,MCPH4,PPP1R55,Spc7,hKNL-1,hSpc105,KNL1,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centromere,Stem Cells,Germline Stem Cells,CASC5
- Molecular Weight
- 195 kDa/205 kDa/262 kDa/265 kDa
- Gene ID
- 57082
- UniProt
- Q8NG31
- Pathways
- Maintenance of Protein Location, Autophagy
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