Calpain S1 antibody (AA 69-268)

Catalog No. ABIN6137928

Product Details anti-Calpain S1 Antibody

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Binding Specificity: AA 69-268

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calpain S1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: ISEAAAQYNP EPPPPRTHYS NIEANESEEV RQFRRLFAQL AGDDMEVSAT ELMNILNKVV TRHPDLKTDG FGIDTCRSMV AVMDSDTTGK LGFEEFKYLW NNIKRWQAIY KQFDTDRSGT ICSSELPGAF EAAGFHLNEH LYNMIIRRYS DESGNMDFDN FISCLVRLDA MFRAFKSLDK DGTGQIQVNI QEWLQLTMYS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human Calpain small subunit 1 (NP_001740.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-Calpain S1 antibody (ABIN6137928)

Liu, Lou, Li, Xu, Ruan, Xiao, Qiu, Bao, Yuan, Huang, Wang, Cao, Chen, Yang, Zhang: "Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells." in: Oncology reports, Vol. 37, Issue 6, pp. 3651-3659, (2018) (PubMed).

Target Details for Calpain S1

Target: Calpain S1 (CAPNS1) (Calpain, Small Subunit 1 (CAPNS1))

Alternative Name: CAPNS1 (CAPNS1 Products)

Background: This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants.,CAPNS1,CALPAIN4,CANP,CANPS,CAPN4,CDPS,CSS1,Signal Transduction,Immunology & Inflammation,T Cell Receptor Signaling Pathway,Neuroscience,Calcium Signaling,CAPNS1

Molecular Weight: 28 kDa

Gene ID: 826

UniProt: P04632

Pathways: Apoptosis