C10orf2 antibody (AA 385-684)

Catalog No. ABIN6137715

Product Details anti-C10orf2 Antibody

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Binding Specificity: AA 385-684

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C10orf2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EQAAGLRWSR FPDLNRILKG HRKGELTVFT GPTGSGKTTF ISEYALDLCS QGVNTLWGSF EISNVRLARV MLTQFAEGRL EDQLDKYDHW ADRFEDLPLY FMTFHGQQSI RTVIDTMQHA VYVYDICHVI IDNLQFMMGH EQLSTDRIAA QDYIIGVFRK FATDNNCHVT LVIHPRKEDD DKELQTASIF GSAKASQEAD NVLILQDRKL VTGPGKRYLQ VSKNRFDGDV GVFPLEFNKN SLTFSIPPKN KARLKKIKDD TGPVAKKPSS GKKGATTQNS EICSGQAPTP DQPDTSKRSK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 385-684 of human C10orf2 (NP_068602.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C10orf2

Target: C10orf2 (C10ORF2) (Chromosome 10 Open Reading Frame 2 (C10ORF2))

Alternative Name: TWNK (C10ORF2 Products)

Synonyms: ATXN8 antibody, IOSCA antibody, MTDPS7 antibody, PEO antibody, PEO1 antibody, PEOA3 antibody, SANDO antibody, SCA8 antibody, TWINL antibody, C6H10orf2 antibody, D19Ertd626e antibody, Twinl antibody, twinkle mtDNA helicase L homeolog antibody, twinkle mtDNA helicase antibody, twnk.L antibody, TWNK antibody, Twnk antibody

Background: This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,TWNK,ATXN8,C10orf2,IOSCA,MTDPS7,PEO,PEO1,PEOA3,PRLTS5,SANDO,SCA8,TWINL,Epigenetics & Nuclear Signaling,Endocrine & Metabolism,Mitochondrial metabolism,Neuroscience,Neurodegenerative Diseases,TWNK

Molecular Weight: 60 kDa/66 kDa/77 kDa

Gene ID: 56652

UniProt: Q96RR1