ATR antibody (AA 400-650)

Catalog No. ABIN6137357

Product Details anti-ATR Antibody

Target: ATR (ATR serine/threonine kinase (ATR))

Binding Specificity: AA 400-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATR antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LKMESMEIIE EIQCQTQQEN LSSNSDGISP KRRRLSSSLN PSKRAPKQTE EIKHVDMNQK SILWSALKQK AESLQISLEY SGLKNPVIEM LEGIAVVLQL TALCTVHCSH QNMNCRTFKD CQHKSKKKPS VVITWMSLDF YTKVLKSCRS LLESVQKLDL EATIDKVVKI YDALIYMQVN SSFEDHILED LCGMLSLPWI YSHSDDGCLK LTTFAANLLT LSCRISDSYS PQAQSRCVFL LTLFPRRIFL E

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 400-650 of human ATR (NP_001175.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ATR

Target: ATR (ATR serine/threonine kinase (ATR))

Alternative Name: ATR (ATR Products)

Synonyms: FCTCS antibody, FRP1 antibody, MEC1 antibody, SCKL antibody, SCKL1 antibody, ATR serine/threonine kinase antibody, ataxia telangiectasia and Rad3 related antibody, ATR antibody, Atr antibody

Background: The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.,ATR,FCTCS,FRP1,MEC1,SCKL,SCKL1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Phosphorylation,DNA Damage & Repair,Cancer,Tumor suppressors,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Mitochondrial Control of Apoptosis,Cell Cycle,G1/S Checkpoint,G2/M DNA Damage Checkpoint,ATR

Molecular Weight: 294 kDa/297 kDa/301 kDa

Gene ID: 545

UniProt: Q13535

Pathways: Positive Regulation of Response to DNA Damage Stimulus