This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants.,APOC1,Apo-CI,ApoC-I,apo-CIB,apoC-IB,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cardiovascular,Heart,Lipids,Fatty Acids,Lipoproteins/Apolipoproteins,Cardiovascular diseases,Heart disease,APOC1