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ALKBH8 antibody (AA 1-230)

ALKBH8 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6136811
  • Target See all ALKBH8 Antibodies
    ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))
    Binding Specificity
    • 15
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-230
    Reactivity
    • 19
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 34
    Rabbit
    Clonality
    • 34
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ALKBH8 antibody is un-conjugated
    Application
    • 13
    • 13
    • 10
    • 8
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    MDSNHQSNYK LSKTEKKFLR KQIKAKHTLL RHEGIETVSY ATQSLVVANG GLGNGVSRNQ LLPVLEKCGL VDALLMPPNK PYSFARYRTT EESKRAYVTL NGKEVVDDLG QKITLYLNFV EKVQWKELRP QALPPGLMVV EEIISSEEEK MLLESVDWTE DTDNQNSQKS LKHRRVKHFG YEFHYENNNV DKDKPLSGGL PDICESFLEK WLRKGYIKHK PDQMTINQYE
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human ALKBH8 (NP_620130.2).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:100 - 1:200
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ALKBH8 (AlkB, Alkylation Repair Homolog 8 (ALKBH8))
    Alternative Name
    ALKBH8 (ALKBH8 Products)
    Synonyms
    ABH8 antibody, 4930562C03Rik antibody, 8030431D03Rik antibody, 9430088N01Rik antibody, Abh8 antibody, alkB homolog 8, tRNA methyltransferase antibody, ALKBH8 antibody, Alkbh8 antibody
    Background
    Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg and tRNA(Glu, and does not bind tRNA(Lys(PubMed:20308323. Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S-methoxycarbonylhydroxymethyluridine, has a preference for tRNA(Gly. Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis.,ALKBH8,ABH8,TRM9,TRMT9,Epigenetics & Nuclear Signaling,Cancer,Tumor biomarkers,ALKBH8
    Molecular Weight
    25 kDa/27 kDa/75 kDa
    Gene ID
    91801
    UniProt
    Q96BT7
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