ABAT antibody (AA 29-300)

Catalog No. ABIN6136330

Product Details anti-ABAT Antibody

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Binding Specificity: AA 29-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABAT antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: SQAAAKVDVE FDYDGPLMKT EVPGPRSQEL MKQLNIIQNA EAVHFFCNYE ESRGNYLVDV DGNRMLDLYS QISSVPIGYS HPALLKLIQQ PQNASMFVNR PALGILPPEN FVEKLRQSLL SVAPKGMSQL ITMACGSCSN ENALKTIFMW YRSKERGQRG FSQEELETCM INQAPGCPDY SILSFMGAFH GRTMGCLATT HSKAIHKIDI PSFDWPIAPF PRLKYPLEEF VKENQQEEAR CLEEVEDLIV KYRKKKKTVA GIIVEPIQSE GG

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human GABA transaminase (GABA transaminase (ABAT)) (NP_001120920.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ABAT antibody (ABIN6136330)

Zeng, Yang, Du, Li, Shen, Liu, Chen, Kamal, Guan, Cheng, Wang, Xu: "Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats." in: Oncotarget, Vol. 8, Issue 60, pp. 102020-102032, (2017) (PubMed).

Target Details for ABAT

Target: ABAT (4-Aminobutyrate Aminotransferase (ABAT))

Alternative Name: ABAT (ABAT Products)

Background: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95 % similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.,ABAT,GABA-AT,GABAT,NPD009,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Amino acid metabolism,Neuroscience,Neurodegenerative Diseases Markers,Other Neurological disorders,ABAT

Molecular Weight: 56 kDa

Gene ID: 18

UniProt: P80404

Pathways: Monocarboxylic Acid Catabolic Process