THRAP3 antibody
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- Target See all THRAP3 Antibodies
- THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This THRAP3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Immunogen
- A synthetic peptide of human THRAP3
- Isotype
- IgG
- Top Product
- Discover our top product THRAP3 Primary Antibody
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- Application Notes
- WB,1:500 - 1:1000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- THRAP3 (Thyroid Hormone Receptor Associated Protein 3 (THRAP3))
- Alternative Name
- THRAP3 (THRAP3 Products)
- Synonyms
- TRAP150 antibody, 9330151F09Rik antibody, B230333E16Rik antibody, Trap150 antibody, trap150 antibody, Thrap3 antibody, MGC132228 antibody, zgc:85716 antibody, thyroid hormone receptor associated protein 3 antibody, DNA cross-link repair 1A protein antibody, thyroid hormone receptor associated protein 3 S homeolog antibody, thyroid hormone receptor-associated protein 3 antibody, thyroid hormone receptor associated protein 3b antibody, THRAP3 antibody, CpipJ_CPIJ018886 antibody, CpipJ_CPIJ019503 antibody, Thrap3 antibody, thrap3 antibody, thrap3.S antibody, thrap3b antibody
- Background
- Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC. Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition, the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex, however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes.,THRAP3,TRAP150,BCLAF2,Epigenetics & Nuclear Signaling,RNA Binding,Nuclear Receptor Signaling,Nuclear hormone receptors,Signal Transduction,THRAP3
- Molecular Weight
- 108 kDa
- Gene ID
- 9967
- UniProt
- Q9Y2W1
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway
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