CD58 antibody (Biotin)

Catalog No. ABIN610161

Product Details anti-CD58 Antibody (Biotin)

Target: CD58

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD58 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Both transmembrane and GPI anchored CD58.

Purification: Protein A purified

Immunogen: Human cytotoxic T cells.

Clone: TS2-9

Isotype: IgG1

Application Details

Application Notes: Approved: Flo, Func

Usage: Function: Inhibits HLA-DR mediated T cell cytotoxicity. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

References for anti-CD58 antibody (Biotin) (ABIN610161)

Dillon, Creer, Kerr, Kümin, Dickson: "Basolateral targeting of ERBB2 is dependent on a novel bipartite juxtamembrane sorting signal but independent of the C-terminal ERBIN-binding domain." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6553-63, (2002) (PubMed).

Piechocki, Pilon, Wei: "Complementary antitumor immunity induced by plasmid DNA encoding secreted and cytoplasmic human ErbB-2." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 6, pp. 3367-74, (2001) (PubMed).

Xu, Mimnaugh, Rosser, Nicchitta, Marcu, Yarden, Neckers: "Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90." in: The Journal of biological chemistry, Vol. 276, Issue 5, pp. 3702-8, (2001) (PubMed).

Target Details for CD58

Target: CD58

Alternative Name: CD58 (CD58 Products)

Synonyms: LFA-3 antibody, LFA3 antibody, ag3 antibody, CD58 molecule antibody, CD58 antibody

Background: Name/Gene ID: CD58
Family: Immunoglobulin

Synonyms: CD58, CD58 antigen, AG3, LFA-3, LFA3, Surface glycoprotein LFA-3, Surface glycoprotein lfa3, CD58 Molecule

Gene ID: 965

UniProt: P19256