SIGLEC7 antibody (PE)
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- Target See all SIGLEC7 Antibodies
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This SIGLEC7 antibody is conjugated to PE
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Application
- Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- Specific for human CDw328, a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.
- Purification
- Affinity purified
- Immunogen
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Monocyte-derived dendritic cells.
Type of Immunogen: Cells - Clone
- 5-386
- Isotype
- IgG1
- Top Product
- Discover our top product SIGLEC7 Primary Antibody
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- Application Notes
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Approved: Flo (1:1), IHC, IHC-Fr
Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute in 1 mL distilled water.
- Concentration
- Lot specific
- Buffer
- Lyophilized powder from PBS, pH 7.4, 0.09 % sodium azide, 1 % BSA, 5 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- avoid freezing
- Storage
- 4 °C
- Storage Comment
- 4°C, avoid freezing.
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- Target
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- Alternative Name
- SIGLEC7 / CD328 (SIGLEC7 Products)
- Synonyms
- SIGLEC7 antibody, AIRM1 antibody, CD328 antibody, CDw328 antibody, D-siglec antibody, QA79 antibody, SIGLEC-7 antibody, SIGLEC19P antibody, SIGLECP2 antibody, p75 antibody, p75/AIRM1 antibody, sialic acid-binding Ig-like lectin 7 antibody, sialic acid binding Ig like lectin 7 antibody, LOC468976 antibody, SIGLEC7 antibody
- Background
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Name/Gene ID: SIGLEC7
Family: Immunoglobulin
Synonyms: SIGLEC7, AIRM-1, AIRM1, CD328 antigen, CDw328, CD328, D-siglec, QA79, SIGLEC-7, QA79 membrane protein - Gene ID
- 27036
- UniProt
- Q9Y286
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