WWOX antibody

Catalog No. ABIN5708495

Product Details anti-WWOX Antibody

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity purified

Immunogen: A recombinant human protein corresponding to amino acids M1-D245 was used as the immunogen for the WWOX antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the WWOX antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL, IHC (FFPE): 1-2 μg/mL, Direct ELISA: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the WWOX antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX (WWOX Products)

Synonyms: CG7221 antibody, DmWWOX antibody, Dmel\\CG7221 antibody, anon-EST:Posey177 antibody, GB11795 antibody, WWOX antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody, zgc:55975 antibody, 5330426P09Rik antibody, 9030416C10Rik antibody, WW domain containing oxidoreductase antibody, WW domain-containing oxidoreductase antibody, Wwox antibody, LOC411815 antibody, WWOX antibody, CpipJ_CPIJ004939 antibody, MCYG_01584 antibody, VDBG_05631 antibody, VDBG_01326 antibody, VDBG_06753 antibody, Tsp_03967 antibody, LOC100284583 antibody, wwox antibody

Background: WW domain-containing oxidoreductase is an enzyme that in humans is encoded by the WWOX gene. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. It spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.

UniProt: Q9NZC7