NUMBL antibody
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- Target See all NUMBL Antibodies
- NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This NUMBL antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Immunogen
- numb homolog (Drosophila)-like
- Isotype
- IgG2a
- Top Product
- Discover our top product NUMBL Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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L02 cells were subjected to SDS PAGE followed by western blot with FNab05918( NUMBLIKE Antibody) at dilution of 1:1000
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze / thaw cycles.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))
- Alternative Name
- NUMBL (NUMBL Products)
- Synonyms
- nbl antibody, numb antibody, cag3a antibody, ctg3a antibody, numbr antibody, numb-r antibody, tnrc23 antibody, numblike antibody, CAG3A antibody, CTG3a antibody, NBL antibody, NUMB-R antibody, NUMBLIKE antibody, NUMBR antibody, TNRC23 antibody, NUMB like, endocytic adaptor protein antibody, numb homolog-like L homeolog antibody, NUMB-like, endocytic adaptor protein antibody, numb-like antibody, NUMBL antibody, numbl.L antibody, Numbl antibody
- Background
- Synonyms: Background:Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
- Molecular Weight
- 65-70 kDa
- Gene ID
- 9253
- UniProt
- Q9Y6R0
- Pathways
- Cell-Cell Junction Organization
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