FZD2 antibody (Internal Region)
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- Target See all FZD2 Antibodies
- FZD2 (Frizzled Family Receptor 2 (FZD2))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Rat, Mouse
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This FZD2 antibody is un-conjugated
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Sequence
- RYATLEHPFH CPR
- Specificity
- Recognizes FZD2 / Frizzled-2.
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- Immunogen
- Peptide with sequence from the internal region of the protein sequence according to NP_001457.1. Genename: FZD2
- Top Product
- Discover our top product FZD2 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- FZD2 (Frizzled Family Receptor 2 (FZD2))
- Alternative Name
- FZD2 / Frizzled-2 (FZD2 Products)
- Synonyms
- BG01711 antibody, CG9739 antibody, D-Fz2 antibody, D-fz2 antibody, DFZ2 antibody, DFz-2 antibody, DFz2 antibody, Dfrz2 antibody, Dfz2 antibody, Dfz[[2]] antibody, Dm Fz2 antibody, Dmel\\CG9739 antibody, FZ2 antibody, Fz2 antibody, dFz2 antibody, dfz(2) antibody, dfz2 antibody, dfz2r antibody, frz2 antibody, fz-2 antibody, fz8 antibody, zfz2 antibody, zg08 antibody, cb383 antibody, wu:fb70g09 antibody, FZD2 antibody, fzE2 antibody, hFz2 antibody, Fz-10 antibody, Fzd10 antibody, cFz-2 antibody, frizzled2 antibody, fz2 antibody, xfz2 antibody, AL033370 antibody, AW456835 antibody, Fz10 antibody, Mfz10 antibody, Mfz10a antibody, frizzled 2 antibody, frizzled class receptor 2 antibody, frizzled class receptor 2 S homeolog antibody, fz2 antibody, fzd2 antibody, FZD2 antibody, Fzd2 antibody, fzd2.S antibody
- Background
- FZD2 is a Frizzled Receptor that mediates Wnt signaling, which is required for proper axis development in the embryo. FZD2 is developmentally regulated. Studies of rat FZD2 indicate that the protein signals through a calcium-releasing pathway and that FDZ2 expression modulates protein kinase C (PKC) localization and stimulates PKC activity in vitro. Increased levels of FZD2 mRNA have been observed in primary gastric cancer and in head and neck squamous carcinoma and gastric cancer cell lines. FZD2 expression has been documented in human brain, heart, kidney, lung, colon, ovary and stomach. High levels of expression have been observed in fetal kidney and lung and adult colon and ovary. ESTs have been isolated from human tissue libraries, including cancerous kidney, lung, lymph and testis, and normal blood, cervix, embryo and kidney.Synonyms: Fz-2, FzE2, hFz2
- Gene ID
- 2535
- NCBI Accession
- NP_001457
- UniProt
- Q14332
- Pathways
- WNT Signaling
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