WAPAL antibody (AA 30-80)

Catalog No. ABIN5690322

Product Details anti-WAPAL Antibody

Target: WAPAL (Wings Apart-Like Protein Homolog (WAPAL))

Binding Specificity: AA 30-80

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WAPAL antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: WAPL antibody is human, mouse and rat reactive. At least four isoforms of WAPL are known to exist.

Purification: WAPL antibody is affinity chromatography purified via peptide column.

Immunogen: WAPL antibody was raised against an 18 amino acid peptide near the amino terminus of human WAPL.

The immunogen is located within amino acids 30 - 80 of WAPL.

Isotype: IgG

Application Details

Application Notes: WAPL antibody can be used for detection of WAPL by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: WAPL antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: WAPL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for WAPAL

Target: WAPAL (Wings Apart-Like Protein Homolog (WAPAL))

Alternative Name: WAPL (WAPAL Products)

Synonyms: RGD1308960 antibody, FOE antibody, KIAA0261 antibody, WAPL antibody, 2410073G16 antibody, A530089A20Rik antibody, BC037674 antibody, mKIAA0261 antibody, mWAPL antibody, WAPL cohesin release factor antibody, Wapl antibody, WAPL antibody, wapl antibody

Background: WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and may play an important role in cell growth (1). It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) (1,2,4). WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits (3,4). WAPL is a new regulator of the development and metastasis of cancerous tissue (4,5).

Molecular Weight: Predicted: 131 kDa

Observed: 140 kDa

Gene ID: 23063

NCBI Accession: NP_055860

UniProt: Q7Z5K2

Pathways: Chromatin Binding