ULK4 antibody (AA 1120-1170)

Catalog No. ABIN5690313

Product Details anti-ULK4 Antibody

Target: ULK4 (ULK24) (Unc-51-Like Kinase 4 (ULK24))

Binding Specificity: AA 1120-1170

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULK4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: ULK4 antibody is human and mouse reactive. Multiple isoforms of ULK4 are known to exist.

Purification: ULK4 antibody is affinity chromatography purified via peptide column.

Immunogen: ULK4 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ULK4.

The immunogen is located within amino acids 1120 - 1170 of ULK4.

Isotype: IgG

Application Details

Application Notes: ULK4 antibody can be used for detection of ULK4 by Western blot at 0.5 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ULK4 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: ULK4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ULK4

Target: ULK4 (ULK24) (Unc-51-Like Kinase 4 (ULK24))

Alternative Name: ULK4 (ULK24 Products)

Synonyms: RGD1565726 antibody, ULK4 antibody, DKFZp459G243 antibody, FAM7C1 antibody, REC01035 antibody, 4932415A06Rik antibody, A730098P15 antibody, unc-51 like kinase 4 antibody, unc-51-like kinase 4 antibody, Ulk4 antibody, ULK4 antibody, ulk4 antibody

Background: ULK4 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1). Knockout of ULK genes results in a severe defect in the autophagy pathway (2). ULK4, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK3, is highly conserved among eukaryotes (3). ULK4 has been implicated as a gene involved in the development of hydrocephalus (3). This neurologic disorder is being used in animal models to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans (4).

Molecular Weight: Predicted: 140 kDa

Observed: 165 kDa

Gene ID: 54986

NCBI Accession: NP_060356

UniProt: Q96C45