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TRIP12 antibody (AA 1930-1980)

TRIP12 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN5690304
  • Target See all TRIP12 Antibodies
    TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))
    Binding Specificity
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1930-1980
    Reactivity
    • 7
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 7
    Rabbit
    Clonality
    • 7
    Polyclonal
    Conjugate
    • 7
    This TRIP12 antibody is un-conjugated
    Application
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Specificity
    TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist.
    Purification
    TRIP12 antibody is affinity chromatography purified via peptide column.
    Immunogen
    TRIP12 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human TRIP12.

    The immunogen is located within amino acids 1930 - 1980 of TRIP12.
    Isotype
    IgG
    Top Product
    Discover our top product TRIP12 Primary Antibody
  • Application Notes
    TRIP12 antibody can be used for detection of TRIP12 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TRIP12 antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    TRIP12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    TRIP12 (Thyroid Hormone Receptor Interactor 12 (TRIP12))
    Alternative Name
    TRIP12 (TRIP12 Products)
    Synonyms
    ULF antibody, TRIP-12 antibody, 1110036I07Rik antibody, 6720416K24Rik antibody, AA410158 antibody, Gtl6 antibody, thyroid hormone receptor interactor 12 antibody, E3 ubiquitin-protein ligase TRIP12 antibody, TRIP12 antibody, CpipJ_CPIJ012812 antibody, PTRG_06487 antibody, LOAG_11488 antibody, LOC100631469 antibody, Trip12 antibody
    Background
    Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1). TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3). TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4). TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5).
    Molecular Weight
    Predicted: 219 kDa

    Observed: 220 kDa
    Gene ID
    9320
    NCBI Accession
    NP_004229
    UniProt
    Q14669
    Pathways
    Nuclear Hormone Receptor Binding
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