zgc:77926 antibody, MGC157051 antibody, GRVS638 antibody, PRO1268 antibody, 1110004B13Rik antibody, 2810049P21Rik antibody, transmembrane protein 107 antibody, Transmembrane protein 107 antibody, transmembrane protein 107 L homeolog antibody, tmem107 antibody, TMEM107 antibody, Tmem107 antibody, Tsp_08866 antibody, tm107 antibody, tmem107.L antibody
Background
Transmembrane protein 107 (TMEM 107) is critical for cilia formation and embryonic patterning (1). It is a 139 amino acid transmembrane protein encoded by a gene that maps to human chromosome 17 which is associated with two key tumor suppressor genes p53 and BRCA1 (1,2). TMEM107 is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types (1,3). TMEM107 is also a strong candidate gene for central areolar choroidal dystrophy (CACD) (1-3).