SKIV2L antibody (AA 260-310)

Catalog No. ABIN5689978

Product Details anti-SKIV2L Antibody

Target: SKIV2L (Superkiller Viralicidic Activity 2-Like (SKIV2L))

Binding Specificity: AA 260-310

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKIV2L antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.

Purification: GPRASP1 antibody is affinity chromatography purified via peptide column.

Immunogen: GPRASP1 antibody was raised against a 15 amino acid peptide near the amino terminus of human GPRASP1.

The immunogen is located within amino acids 260 - 310 of GPRASP1.

Isotype: IgG

Application Details

Application Notes: GPRASP1 antibody can be used for detection of GPRASP1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GPRASP1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: GPRASP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for SKIV2L

Target: SKIV2L (Superkiller Viralicidic Activity 2-Like (SKIV2L))

Alternative Name: SKI2W (SKIV2L Products)

Background: The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2). GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2). Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3).

Molecular Weight: Predicted: 153 kDa

Observed: 150 kDa

Gene ID: 9737

NCBI Accession: NP_001171656

UniProt: Q5JY77