TWIST2 antibody (AA 26-30)

Catalog No. ABIN5689370

Product Details anti-TWIST2 Antibody

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Binding Specificity: AA 26-30

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TWIST2 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous level of total Twist2 protein.

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Twist2 antibody was raised against a peptide sequence around aa.26~30 (P-K-R-F-G) derived from Human Twist2.

Application Details

Application Notes: Western Blot: 1:500~1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store antibody at -20°C for up to one year.

Target Details for TWIST2

Target: TWIST2 (Twist Homolog 2 (TWIST2))

Alternative Name: Twist2 (TWIST2 Products)

Synonyms: TWIST2 antibody, DERMO1 antibody, FFDD3 antibody, SETLSS antibody, bHLHa39 antibody, Dermo1 antibody, CDERMO-1 antibody, twist family bHLH transcription factor 2 antibody, twist basic helix-loop-helix transcription factor 2 antibody, TWIST2 antibody, Twist2 antibody

Background: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors.

Molecular Weight: 18 kDa

Gene ID: 117581

NCBI Accession: NP_476527

UniProt: Q8WVJ9

Pathways: Chromatin Binding