Connexin antibody (C-Term)
Reactivity: Sheep, Xenopus laevis, Zebrafish (Danio rerio), Chicken, Dog, Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
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- Target See all Connexin products
- Connexin
- Binding Specificity
- C-Term
- Reactivity
- Sheep, Xenopus laevis, Zebrafish (Danio rerio), Chicken, Dog, Human, Mouse, Rat
- Host
- Rabbit
- Clonality
- Polyclonal
- Application
- Western Blotting (WB)
- Purification
- Affinity Purified
- Immunogen
- Peptide corresponding to amino acid residues from the C-terminal region of rat connexin43.
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- Application Notes
- The antibody has been directly tested for reactivity in Western blots in rat tissues. It is anticipated that the antibody will also work with chicken, dog, finch, human, mouse, non-human primate, sheep, Xenopus and zebra fish tissues based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
- Storage
- -20 °C
- Storage Comment
- Connexin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
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- Target
- Connexin
- Abstract
- Connexin Products
- Synonyms
- connexin antibody, LOC100128922 antibody
- Background
- Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin43 is known to be regulated by phosphorylation at er368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
- Molecular Weight
- 43 kDa
- Gene ID
- 24392
- UniProt
- P08050
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