TBC1D4 antibody (AA 574-712)

Catalog No. ABIN5684096

Product Details anti-TBC1D4 Antibody

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Binding Specificity: AA 574-712

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBC1D4 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Purpose: TBC1D4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TBC1D4 (AA: 574-712) expressed in E. Coli.

Clone: 8A11A2

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Alternative Name: TBC1D4 (TBC1D4 Products)

Background:

Description: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: AS160, NIDDM5

Molecular Weight: 146.5kDa

Gene ID: 9882

HGNC: 23495

UniProt: O60343