TXNIP antibody

Catalog No. ABIN567793

Product Details anti-TXNIP Antibody

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TXNIP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificity: This antibody reacts with VDUP-1 (50 kDa) by Western blotting.

Purification: Protein-A Agarose Chromatography of hybridoma supernatant.

Immunogen: Human recombinant VDUP-1/Txnip.

Clone: JY1

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 50 % Glycerol without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Alternative Name: TXNIP / VDUP1 (TXNIP Products)

Synonyms: EST01027 antibody, HHCPA78 antibody, THIF antibody, VDUP1 antibody, Gm348 antibody, Trf3 antibody, TBP2 antibody, TRF3 antibody, 1200008J08Rik antibody, AA682105 antibody, Hyplip1 antibody, Tbp-2 antibody, Vdup1 antibody, sb:cb368 antibody, txnip antibody, thioredoxin interacting protein antibody, TATA box binding protein like 2 antibody, TATA-box binding protein like 2 antibody, thioredoxin interacting protein L homeolog antibody, thioredoxin interacting protein a antibody, TXNIP antibody, Tbpl2 antibody, TBPL2 antibody, Txnip antibody, txnip.L antibody, txnip antibody, txnipa antibody

Background: Vitamin D3 up-regulated protein 1 (VDUP-1), also called Thioredoxin (TRX)-interacting protein, is an endogenous inhibitor of TRX. Redox-dependent regulation of VDUP-1 by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of VDUP-1 to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX.Synonyms: Thioredoxin-binding protein 2, Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1

Gene ID: 10628

NCBI Accession: NP_006463

UniProt: Q9H3M7

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome