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MAD2L1 antibody
MAD2L1
Reactivity: Human, Mouse, Rat
WB, IP
Host: Mouse
Monoclonal
2G9
unconjugated
Product Details anti-MAD2L1 Antibody
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Target
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MAD2L1
(MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1))
Reactivity
All reactivities for MAD2L1 antibodies
Human, Mouse, Rat
Host
All hosts for MAD2L1 antibodies
Mouse
Clonality
All clonalities for MAD2L1 antibodies
Monoclonal
Conjugate
All conjugates for MAD2L1 antibodies
This MAD2L1 antibody is un-conjugated
Application
All applications for MAD2L1 antibodies
Western Blotting (WB), Immunoprecipitation (IP)
Specificity
This antibody reacts with MAD2 (25 kDa) on Western blotting and Immunoprecipitation.
Purification
Protein-A Agarose Chromatography of hybridoma supernatant.
Immunogen
Recombinant Human MAD2.
Clone
2G9
Isotype
IgG1
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative
Without preservative
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody (in aliquots) at -20 °C.
Target Details for MAD2L1
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Target
MAD2L1
(MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1))
Alternative Name
MAD2L1 (MAD2L1 Products )
Synonyms
HSMAD2 antibody, MAD2 antibody, MXD2 antibody, MXI antibody, bHLHc11 antibody, AA673185 antibody, cb408 antibody, zgc:112133 antibody, mad2 antibody, XMad2 antibody, MAD2L1 antibody, mitotic arrest deficient 2 like 1 antibody, MAX interactor 1, dimerization protein antibody, MAD2 mitotic arrest deficient-like 1 antibody, MAD2 mitotic arrest deficient-like 1 (yeast) antibody, mitotic arrest deficient 2 like 1 S homeolog antibody, MAD2L1 antibody, MXI1 antibody, Mad2l1 antibody, mad2l1 antibody, mad2l1.S antibody
Background
Some of the spindle checkpoint components are evolutionarily conserved from yeast to human. They include mitotic arrest deficiency 1 (MAD1), MAD2, MAD3/BUBR1, budding uninhibited by benomyl 1 (BUB1), BUB3, and monopolar spindle 1 (MPS1). MAD1 interacts with several checkpoint proteins, forming a complex with MAD2 and recruiting MAD2 to unattached kinetochores. MAD1 and Cdc20 can bind MAD2, but these two bindings are exclusive. They share a 10-residue MAD2-binding motif. It has been suggested that MAD1 acts as a positive regulator and a competitive inhibitor of the MAD2-Cdc20 complex.Synonyms: MAD2, Mitotic spindle assembly checkpoint protein MAD2A
Gene ID
4085
NCBI Accession
NP_002349
UniProt
Q13257
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