NQO2 antibody

Catalog No. ABIN567621

Product Details anti-NQO2 Antibody

Target: NQO2

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This NQO2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: The antibody recognizes human and mouse NQO2. Other species not tested.

Purification: Protein-G affinity chromatography

Clone: AT1E3

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for NQO2

Target: NQO2

Alternative Name: NQO2 (NQO2 Products)

Synonyms: DHQV antibody, DIA6 antibody, NMOR2 antibody, QR2 antibody, NMO2 antibody, Nmor2 antibody, Ox2 antibody, N-ribosyldihydronicotinamide:quinone reductase 2 antibody, N-ribosyldihydronicotinamide quinone reductase 2 antibody, NQO2 antibody, Nqo2 antibody

Background: Quinone oxidoreductase (NQO1 and NQO2) are cytosolic proteins that catalyze metabolic redaction of quinines and derivates.NQO2 is inhibited by flavones such as quercetin. Also benzo(a)pyrene is another known inhibitor of NQO2. Even though overlapping substrates specificities have been observed for NQO1 and NQO2, such as for CB1954 activation, significant differences exist in relative affinities for the various substrates.The detoxification role of NQO2 has not been found, and it has no known endogenous biological substrates. However, NQO1 plays an important role in the detoxification of various endogenous and exogenous quinones, including estrogen quinines. Also NQO2 has a melatonin-binding site, which may explain the anti-oxidant role of melatonin related with circadian rhythm.Synonyms: NMOR2, NRH dehydrogenase [quinone] 2, NRH:quinone oxidoreductase 2, Ribosyldihydronicotinamide dehydrogenase [quinone]

Gene ID: 4835