UMPS antibody (AA 351-450)

Catalog No. ABIN5675133

Product Details anti-UMPS Antibody

Target: UMPS (Uridine Monophosphate Synthetase (UMPS))

Binding Specificity: AA 351-450

Reactivity: Human, Cynomolgus, Rhesus Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UMPS antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Cynomolgus, Human, Rhesus Monkey

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UMPS

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for UMPS

Target: UMPS (Uridine Monophosphate Synthetase (UMPS))

Alternative Name: UMPS (UMPS Products)

Synonyms: zgc:55702 antibody, zgc:55723 antibody, UMPS antibody, OPRT antibody, 1700095D23Rik antibody, AA408257 antibody, AL033308 antibody, BB164745 antibody, Orotidine 5'-phosphate decarboxylase antibody, uridine monophosphate synthetase antibody, uridine monophosphate synthetase L homeolog antibody, uridine 5'-monophosphate synthase antibody, umps-1 antibody, umps antibody, umps.L antibody, UMPS antibody, LOC100556619 antibody, Umps antibody

Background:

Synonyms: Uridine 5'-monophosphate synthase, UMPS, UMP synthase, Orotate phosphoribosyltransferase, OPRT, OPRTase, ODC, OMPdecase, OK/SW-cl.21

Background: This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.

Gene ID: 7372

UniProt: P11172

Pathways: Ribonucleoside Biosynthetic Process